TABLE 2.
Biological Process Associated with Genes Up-Regulated in Expanded NK Cells
| Biological Process | Observed Genes | Total Genes | Expected by Chance | O/E* |
|---|---|---|---|---|
| Cell killing | 12 | 30 | 3.8 | 3.19 |
| Viral reproduction | 16 | 67 | 8.4 | 1.90 |
| Cellular component biogenesis | 126 | 676 | 84.8 | 1.49 |
| Cellular component organization | 284 | 1687 | 211.7 | 1.34 |
| Anatomical structure formation | 122 | 764 | 95.9 | 1.27 |
| Metabolic process | 816 | 5213 | 654.1 | 1.25 |
| Death | 124 | 807 | 101.3 | 1.22 |
| Establishment of localization | 246 | 1692 | 212.3 | 1.16 |
| Cellular process | 1077 | 7440 | 933.5 | 1.15 |
| Localization | 292 | 2022 | 253.7 | 1.15 |
| Growth | 38 | 265 | 33.2 | 1.14 |
| Rhythmic process | 10 | 70 | 8.8 | 1.14 |
| Negative regulation of biological process | 157 | 1107 | 138.9 | 1.13 |
| Multi-organism process | 60 | 438 | 55.0 | 1.09 |
| Immune system process | 99 | 728 | 91.3 | 1.08 |
| Positive regulation of biological process | 161 | 1198 | 150.3 | 1.07 |
| Response to stimulus | 267 | 2017 | 253.1 | 1.06 |
| Biological regulation | 581 | 4497 | 564.2 | 1.03 |
| Regulation of biological process | 543 | 4284 | 537.5 | 1.01 |
| Locomotion | 40 | 319 | 40.0 | 1.00 |
| Developmental process | 227 | 1920 | 240.9 | 0.94 |
| Reproductive process | 44 | 394 | 49.4 | 0.89 |
| Reproduction | 44 | 396 | 49.7 | 0.89 |
| Multicellular organismal process | 219 | 2231 | 279.9 | 0.78 |
| Biological adhesion | 38 | 436 | 54.7 | 0.69 |
| Pigmentation | 1 | 32 | 4.0 | 0.25 |
*
Ratio of observed number to expected number