Fig. 1.

Biochemical pathways leading to the synthesis of TAG and cholesterol. Glycolytic pathway generates Acetyl CoA from glucose imported into the cell through GLUT2. TAG and cholesterol are synthesized from Acetyl CoA by sequential enzymatic actions. GLUT2 Glucose transporter 2, GK glucokinase, L-PK liver pyruvate kinase, PEP phosphoenolpyruvate, ACC acetyl-CoA carboxylase, FASN fatty acid synthase, SCD stearoyl-CoA desaturase, GPAT glycerol-3-phosphate acyltransferase, DGAT diacylglycerol acyltransferase, HMG-CoA 3-hydroxy-3-methylglutaryl-coenzyme A, HMGCS HMG-CoA synthase, HMGCR HMG-CoA reductase