Table 1. Major and minor diagnostic criteria of CRMO.

Major diagnostic criteria	Minor diagnostic criteria
Radiologically proven osteolytic/osteosclerotic bone lesions	Normal blood cell count and good general state of health
Multifocal bone lesions	CRP and ESR mildly to moderately elevated
Psoriasis or pustulosis palmoplantaris	Course longer than 6 months
Sterile bone biopsy with signs of inflammation and sclerosis	Hyperostosis
	Association with other autoimmune disease
	Grade I or II relatives with autoimmune or inflammatory disorder or non-bacterial osteitis