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Identification of highly potent soloRNA compounds. A panel of soloRNAs corresponding (identical seed region) to previously identified functional 25-bp RNAi duplexes against the SOD1 gene were transfected at 1 nM into HEK293 cells. SOD1 expression (normalized to PPIB) was evaluated at 48 h using a bDNA assay. Error bars represent the standard deviation of biological triplicates.
