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. 2010 Oct 27;30(43):14390–14398. doi: 10.1523/JNEUROSCI.2167-10.2010

Figure 2.

Figure 2.

Behavioral performance on the place discrimination in experiment 1. Each rat received bilateral infusions of saline (Sal) or one of three different doses of Bac–Mus into the Pf 5 min before each test session. The treatments on the x-axis represent the treatment received before acquisition (top) and before reversal learning (bottom). A, Mean ± SEM trials to criterion on place acquisition. Infusion of Bac–Mus had no effect on acquisition. B, Mean ± SEM trials to criterion on place reversal learning. The middle and high dose of Bac–Mus significantly impaired reversal learning. *p < 0.05 versus saline/saline, Bac–Mus/saline, and saline/Bac–Mus low dose. **p < 0.01 versus saline/saline, Bac–Mus/saline, and saline/ Bac–Mus low dose. C, Mean ± SEM perseverative errors committed during reversal learning. Bac–Mus treatment did not affect the number of perseverative errors. D, Mean ± SEM regressive errors committed during reversal learning. The middle and high dose of Bac–Mus significantly increased regressive errors. +p < 0.05 versus saline/saline, Bac–Mus/saline, and saline/Bac–Mus low dose. ++p < 0.01 versus saline/saline, Bac–Mus/saline, saline/Bac–Mus low dose, and saline/Bac–Mus high dose.