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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Curr Opin Lipidol. 2011 Apr;22(2):86–92. doi: 10.1097/MOL.0b013e3283428d9d

Figure 2. miR-33 represses expression of genes involved in cholesterol export and fatty acid oxidation.

Figure 2

Activation of Srebf-1 or Srebf-2 results in co-transcription of miR-33b and miR-33a, respectively. These miRNAs simultaneously inhibit the expression of genes involved in fatty acid metabolism (CROT, CPT1a, HADHB) and cholesterol transport (ABCA1, ABCG1, NPC1). The outcome of miR-33a/b activation is reduced fatty acid β-oxidation and decreased movement of cholesterol into the HDL pathway.