Figure 2.

Hereditary breast and ovarian cancer syndrome (HBOCS) cancer risk management intensity score for healthy at-risk relatives. Histogram and median score of physician responders in four different situations: A) sister of a relative with breast cancer and no testing performed (Case 1), B) daughter who is negative for BRCA1 deleterious mutation found in mother (Case 2a), C) daughter positive for BRCA1 deleterious mutation found in mother (Case 2b) and D) sister positive for BRCA1 variant of uncertain significance (VUS) found in woman with breast cancer (Case 3).

Distributions for the woman with a deleterious mutation (C)* and VUS (D)# are each different from the other 3 (Wilcoxon signed rank test, p<0.0001). Distributions for no testing (A) and negative (B) result are not different from each other (Wilcoxon signed rank test, p=0.071).