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. Author manuscript; available in PMC: 2011 May 17.
Published in final edited form as: J Infect Dis. 2010 May 15;201(10):1551–1560. doi: 10.1086/651949

Table 2.

Genetic Characteristics of the 13 Microsatellite Loci around pfmdr1 on Chromosome 5 and 8 Neutral Microsatellite Loci (4 Each on Chromosomes 2 and 3) Based on pfmdr1 Copy Number and 184F Mutation

Loci Based on copy number Based on Y184F
Single copy
(n = 62)		 Multiple copies
(n = 31)		 184Y
(n = 43)		 184F
(n = 50)
A He ± SD A He ± SD A He ± SD A He ± SD
pfmdr1
  −99 kb 13 0.84 ± 0.03   8 0.70 ± 0.07 11 0.89 ± 0.01 10 0.63 ± 0.07
  −54 kb 12 0.75 ± 0.04   7 0.74 ± 0.06 12 0.88 ± 0.02   7 0.56 ± 0.07
  −29.5 kb 14 0.73 ± 0.05   9 0.79 ± 0.05 14 0.92 ± 0.01   7 0.49 ± 0.07
  −9.3 kb   7 0.72 ± 0.04   7 0.77 ± 0.05   8 0.82 ± 0.02   6 0.50 ± 0.07
  −4.2 kb 11 0.76 ± 0.04 11 0.81 ± 0.05 13 0.90 ± 0.01   7 0.49 ± 0.07
  −3.3 kb 12 0.78 ± 0.03 10 0.85 ± 0.02 14 0.90 ± 0.02   4 0.55 ± 0.02
  0 kb   8 0.73 ± 0.02   8 0.67 ± 0.07 10 0.72 ± 0.05   5 0.51 ± 0.06
  0.16 kb 10 0.81 ± 0.02   7 0.79 ± 0.03 12 0.87 ± 0.02   5 0.63 ± 0.03
  0.45 kb 10 0.56 ± 0.07   6 0.67 ± 0.05   9 0.79 ± 0.03   5 0.22 ± 0.07
  3.6 kb 14 0.85 ± 0.02   9 0.80 ± 0.04 13 0.91 ± 0.01   7 0.67 ± 0.05
  9.1 kb   5 0.67 ± 0.03   6 0.67 ± 0.05   7 0.70 ± 0.05   5 0.61 ± 0.03
  23.3 kb 11 0.86 ± 0.02 11 0.89 ± 0.02 12 0.90 ± 0.01 10 0.85 ± 0.02
  89 kb   5 0.71 ± 0.02   5 0.75 ± 0.03   6 0.78 ± 0.01   4 0.62 ± 0.03
    Mean value 10.15 0.75 ± 0.03   8 0.76 ± 0.04 10.84 0.84 ± 0.02   6.30 0.56 ± 0.05
Chr 2a
  C2M27 13 0.91 ± 0.02 12 0.91 ± 0.02 14 0.92 ± 0.01 12 0.85 ± 0.03
  C2M29 10 0.68 ± 0.06   9 0.77 ± 0.07 10 0.74 ± 0.06 11 0.71 ± 0.06
  C2M34 17 0.91 ± 0.02 17 0.95 ± 0.01 15 0.92 ± 0.01 17 0.91 ± 0.02
  C2M33 15 0.89 ± 0.02 11 0.89 ± 0.02 14 0.92 ± 0.01 14 0.88 ± 0.02
    Mean value 13.75 0.85 ± 0.05 12.25 0.88 ± 0.03 13.25 0.87 ± 0.04 13.50 0.84 ± 0.04
Chr 3a
  C3M40 16 0.89 ± 0.02 14 0.93 ± 0.02 15 0.91 ± 0.02 14 0.87 ± 0.02
  C3M88 16 0.91 ± 0.01 11 0.92 ± 0.01 12 0.91 ± 0.01 13 0.91 ± 0.01
  C3M69 11 0.85 ± 0.02   8 0.82 ± 0.03 11 0.88 ± 0.02 10 0.82 ± 0.03
  C3M39   6 0.44 ± 0.07   3 0.31 ± 0.11   6 0.59 ± 0.07   3 0.19 ± 0.07
    Mean value 12.25 0.77 ± 0.11 12.25 0.75 ± 0.14 11 0.82 ± 0.07 10 0.71 ± 0.16

NOTE. The isolates were considered as multiple copy isolates if they contained ≥2 copies of pfmdr1 gene as determined by real-time quantitative polymerase chain reaction. A, number of alleles per locus; He, expected heterozygosity; SD, standard deviation.

a

The GenBank accession numbers for these neutral microsatellite loci on chromosomes 2 and 3 are G37889, G37891, G37995, G37886, G37979, G42719, G37915, and G37913.