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. Author manuscript; available in PMC: 2011 May 17.
Published in final edited form as: Toxicol Pathol. 2010 Dec 21;39(1):240–266. doi: 10.1177/0192623310391680

Figure 2.

Figure 2

Cholangiofibrosis in the rat. (A) A low-magnification image of a liver lobe from a F344/N rat treated with a high dose of furan for several months. A large portion of the lobe has been replaced by cholangiofibrosis with focal areas of regenerative hepatocellular hyperplasia. The overall contour of the lobe has not been appreciably expanded. (B) A different lobe from the same rat as in (A) with a localized contracted area of cholangiofibrosis. The remainder of the lobe is relatively normal. (C) Low-magnification image of a liver lobe from a F344/N rat treated with a high dose of furan for several months. Two protruding nodules of cholangiofibrosis on the surface of the liver consist of markedly dilated, mucus-filled glands. The remainder of the lobe is occupied by resolving sclerotic remnants of cholangiofibrosis. (D) Cholangiofibrosis diffusely distributed in the liver of a Sprague-Dawley rat treated with a high dose of a dioxin-related xenobiotic. Both small and mucus-filled, dilated biliary glands are present. (E) High magnification of 11D showing mucus-filled dilated glands with partial loss of glandular epithelium surrounded by inflammatory cell infiltrates and fibrosis. H&E.