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“Intramural plaque” in a blood vessel of the mouse lung. (A–C) Lesion from an untreated manganese superoxide dismutase (MnSOD) mouse. Granular, amorphous material with a spindloid cell component is present between the endothelium and the tunica media; a small focus of similar material is present between the tunica media and the tunica adventitia. The asterisk in (A) indicates a pulmonary vein, identifiable by the cardiomyocytes in the vessel wall. H&E.
