Table 1.

Pulegone study design and results.

3 month male & female mice	0	9.375	18.75	37.5	75	150
3 month male rats	0	9.375	18.75	37.5	75*2/10	150*10/10
3 month female rats	0	9.375	18.75	37.5	75	150*8/10
2 year male mice	0	–	–	37.5*19/50	75*30/50	150*44/50
2 year female mice	0	–	–	37.5*3/50	75*15/50	150*41/50
2 year male rats	0	–	18.75	37.5*9/50	75*24/50	–
2 year female rats	0	–	–	37.5*17/50	75*49/50	150*48/49

Asterisks indicate groups in which hyaline glomerulopathy was observed in renal glomeruli. A dash indicates no dose. When the lesion was present, the incidence is indicated. Due to excessive morbidity and mortality, males given 75 mg/kg and females given 150 mg/kg did not receive pulegone after week 60 (stop-exposure), but instead were treated with corn oil vehicle until the end of the study.