Figure 17.11.5.

Matrix method of screening chemical libraries. A library containing 289 dipeptide compounds is screened by examining individual mixtures located in the first row and first column of a matrix plate. Mixtures that result in similar changes in the in-cell NMR spectrum, so called hits, located at the intersection of rows (red) and columns (blue), are used in the second round of screening to validate the hit. Reprinted with permission from Xie et al (2009). For the color version of this figure go to http://www.currentprotocols.com/protocol/ps1711.