Figure 2.
Regional spinal cord blood flow (SCBF) was determined using fluorescent microspheres (as detailed in the text) at various time points following serial ligation of all segmental arteries (TAASA). No segmental artery sacrifice was carried out in the controls. Pigs in the recovery group subsequently regained hind limb function, but those in the paraparetic/paraplegia group suffered permanent spinal cord injury. The dashed lines represent baseline flows at 32ºC during anesthesia, and after awakening, at 37ºC. The three graphs represent cervical and upper thoracic, lower thoracic and upper lumbar, and lumbosacral regions of the spinal cord, as indicated. The first baseline was recorded at 32ºC under anesthesia, and the second at 72 hrs. It is notable that there were no significant differences among the groups in the cervical region of the cord. Below this level, however, there was a significant difference between the paraparetic animals and the controls at five hours, with the controls exhibiting a marked hyperemia. There were no significant differences among the groups at the later time points.