FIG. 4.

Monofunctional DNA glycosylase–initiated BER pathway. Repair of adenosine when opposite the oxidative base lesion 8-oxodG, as initiated by the monofunctional DNA glycosylase MYH. The chemistry of the lesion and the repair intermediates throughout the repair process are shown (center), highlighting the three essential steps for BER: lesion recognition/strand scission, gap tailoring, and DNA synthesis/ligation (left). The structures on the right depict the protein complexes required for completion of each step in BER initiated by MYH.