Table 1.

Summary of Human Bifunctional DNA Glycosylases (with Associated β-Elimination) for Repair of Oxidatively Damaged DNA

Gene symbol	Gene name	Gene ID	Uniprot accession number	Organelle expressed	Known substratea
OGG1	8-oxoguanine DNA glycosylase	4968	O15527	Nucleus and mitochondria	8-oxoG:C/T/G; me-FapyG:C; FapyG:C (4) 8-oxoA:C (43) urea (9)
NTHL1 (NTH1)	nth endonuclease III-like 1 (E. coli)	4913	P78549	Nucleus and mitochondria	T or C-glycol; FapyA (4) 5,6-dihydro-U:G/A (9) 5-formyl-U (9) 5,6-dihydroxy-C (9) 5,6-dihydro-T (9) urea (9) 5-OH-U:G (9) 5-OH-C:G>A (9) 5-hydroxy-5,6,-dihydro-T (9) 8-oxoG:G (65)
NEIL3	Nei endonuclease VIII-like 3 (E. coli)	55247	Q8TAT5	Nucleus	Spiroiminodihydantoin (Sp):C (55) Guanidinohydantoin (Gh):C (55) FapyA (55) FapyG (55) 5-OH-U (55) 5-OH-C (55) Tg (55)

^aTarget base on left in mismatches.