Table 2.
Summary of Human Monofunctional DNA Glycosylases for Repair of Oxidatively Damaged DNA
| Gene symbol | Gene name | Gene ID | Uniprot accession number | Organelle expressed | Known substratea |
|---|---|---|---|---|---|
| UNG | Uracil DNA glycosylase | 7374 | P13051 | Nucleus (UNG2) and mitochondria (UNG1) | ssU; U:G; U:A; 5-fluorouracil (4) 5,6-Dihydroxy-U:G (9) and 5-OH-U:G (9, 22) Isodialuric acid and Alloxan (22) |
| SMUG1 | Single-strand–selective monofunctional uracil-DNA glycosylase 1 | 23583 | Q53HV7 | Nucleus | ssU; U:G; U:A (4) 5-Fluorouracil:G and 5-chlorouracil:G (18) 5-Carboxyuracil:G (18) 5-(Hydroxymethyl)-U (9, 91) 5-Formyl-U and 5-hydroxyuracil (9) |
| TDG | Thymine DNA glycosylase | 6996 | Q13569 | Nucleus | U:G; T:G and ethenoC:G (4) 5-Fluorouracil and 5-fluorouracil (ss) (38) 5-Hydroxymethyluracil (38) hypoxanthine:G, 5-bromouracil and ɛC:A (38) Tg:G (96) and 5-formyl-U (9) |
| MBD4 | Methyl-CpG binding domain protein 4 | 8930 | O95243 | Nucleus | U or T in U/TpG; 5-meCpG (4) 5-Formyluracil (9) 5-(Hydroxymethyl)-U (9) Tg:G (96) |
| MPG (AAG) | N-methyl DNA glycosylase | 4350 | P29372 | Cytoplasm and nucleus | 3-meA; 7-meA; 3-meG; 7-meG; hypoxanthine and ethenoA; ethenoG (4) 1,N2-ɛG:C; U:G and ethanoadenine and 1-methylguanine (53) Etheno-A(ss); hypoxanthine(ss) and ssU (53) 8-OxoG:C (Mouse) (7) Cyanuric acid:CT>GA (9) |
| MUTYH (MYH) | mutY homologue (E. coli) | 4595 | Q9UIF7 | Nucleus and mitochondria | A:G; A:8-oxoG and C:A; 2-OH-A (4) 8-OxoA:G (72) |
a
Target base on left in mismatches.