Table 3.
Summary of Human Bifunctional DNA Glycosylases (with Associated β,δ-Elimination) for Repair of Oxidatively Damaged DNA
| Gene symbol | Gene name | Gene ID | Uniprot accession number | Organelle expressed | Known substratea |
|---|---|---|---|---|---|
| NEIL1 | Nei endonuclease VIII-like 1 (E. coli) | 79661 | Q96FI4 | Nucleus, cytoplasm and mitochondria (mouse) | TgG; 5-OH-C; 5-OH-U:AT>G (4) Guanidinohydantoin (35) guanidinohydantoin (ss) (35) Iminoallantoin (35) Iminoallantoin (ss) (35) Spiroiminodihydantoin (35) Spiroiminodihydantoin (ss) (35) 5,6-Dihydro-T (9) 5,6-Dihydro-U:G/C/A>T (9) FapyG:C (9) 8-Oxo-G:C/G>T>A (9) FapyA:T (9) (5′R)-8,5′-Cyclo-2′-deoxyadenosine (42) (5′S)-8,5′-Cyclo-2′-deoxyadenosine (42) 8-Oxo-A:C (31) |
| NEIL2 | Nei-like 2 (E. coli) | 252969 | Q969S2 | Nucleus and cytoplasm | 5-OH-U:G>T>A; 5-OH-C (4) 5,6-Dihydro-U:G/A (9) 8-Oxo-G:C/A (9) 5,6-Dihydrothymine (9) Guanidinohydantoin (35) Guanidinohydantoin (ss) (35) Iminoallantoin (35) Iminoallantoin (ss) (35) Spiroiminodihydantoin (ss) (35) |
a
Target base on left in mismatches.