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An Hsp70 binding site identified by systematic deletion analysis and in silico modeling (84, 196). The 150–228 and, more precisely, 184–221 fragment (shown in dark gray and cartoon representation) and Arg192 and Lys194 in human AIF were identified as important for Hsp70 binding. Since the predicted site includes a redox-sensitive 191–203 β-hairpin, interaction between AIF and Hsp70 may be redox controlled.
