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A potential binding site for phospholipid scramblase derived based on the sequence homology between human AIF and C. elegans WAH-1 (231). The 270–440 fragment and Lys337 in human AIF (highlighted in black) correspond to the WAH-1 380–550 peptide and Lys446, which are critical for interaction with SCRM-1, a worm homolog of human scramblase. The predicted scramblase-binding site includes residues comprising the NAD(H)- and FAD-binding domains.
