FIG. 6. .

Efficacy of lethally inactivated RM-1α vaccine cells. Mice were inoculated intraperitoneally (i.p.) on days –35, –28, –21, –14, –7, and 0 with 10⁶ inactivated RM-1α vaccine cells. The inactivated RM-1α vaccine cells were pretreated for >2 weeks with 300 or 3,000 IU/mL of interferon-α (IFN-α). Control mice were mock inoculated with the carrier (HBSS). On day 0, all mice were challenged i.p. with 10⁵ live RM-1 parental cells. The graph plots the combined data of 2 experiments (10 mice per group in each of 2 experiments) as percent survival (mean ± SE) versus types of vaccine. Fisher’s exact test for HBSS-treated versus vaccinated vaccine cells treated with 300 IU/mL of IFN-α: P = 0.01; HBSS-treated versus vaccinated with vaccine cells treated with 3,000 IU/mL of IFN-α: P < 0.0001; vaccinated with vaccine cells treated with 300 IU/mL of IFN-α versus vaccinated with vaccine cells treated with 3,000 IU/mL of IFN-α: P = 0.043.