Table 2.

Genes which showed statistically significant differential gene expression in various cell types from patients affected by Paget’s disease of bone

Gene symbol	Encoded protein	Human cell type	Reference
Downregulated genes
ACP5	Acid phosphatase 5, tartrate resistant	Osteoclast*	154
CASP3	Caspase 3, apoptosis-related cysteine peptidase	Osteoclast*	154
CTSK	Cathepsin K	Osteoclast*	154
FLJ23191	Chromosome 4 open reading frame 31	Osteoblast	2
GCA	Grancalcin, EF-hand calcium binding protein	Osteoblast	2
GLRB	Glycine receptor, beta	Osteoblast	2
MAFB	V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	Osteoblast	2
MAPT	Microtubule-associated protein tau	Osteoclast*	154
SATB2	SATB homeobox 2	Osteoblast	2
TNFα	Tumor necrosis factor	Monocytes Lymphocytes	155
TNFRSF10A	Tumor necrosis factor receptor superfamily, member 10a	Osteoclast*	154
TNFRSF11A	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Osteoclast*	154
Upregulated genes
EPB41L4B	Erythrocyte membrane protein band 4.1 like 4B	Osteoblast	2
GULP1	GULP, engulfment adaptor PTB domain containing 1	Osteoblast	2
IFNα	Interferon, alpha 1	Monocytes Lymphocytes	155
IFNβ	Interferon, beta 1, fibroblast	Monocytes Lymphocytes	155
IFNγ	Interferon, gamma	Monocytes Lymphocytes	155
IFNγ-R1	Interferon gamma receptor 1	Monocytes Lymphocytes	155
IFNγ-R2	Interferon gamma receptor 2 (interferon gamma transducer 1)	Monocytes Lymphocytes	155
KRT18	Keratin 18	Osteoblast	2
P38 β2 MAPK	Mitogen-activated protein kinase 14	Monocytes	155
RAI3	G protein-coupled receptor, family C, group 5, member A	Osteoblast	2
RBPMS	RNA binding protein with multiple splicing	Osteoblast	2
STAT1	Signal transducer and activator of transcription 1, 91 kDa	Monocytes	155
STAT2	Signal transducer and activator of transcription 2, 113 kDa	Lymphocytes	155
TNXB	Tenascin XB	Osteoblast	2

Note:

^*Peripheral blood monocytes differentiated in vitro into mature osteoclasts.