Table 2. .
Entrapment Efficiency of Nanoparticles Prepared by Dialysis Method and O/W Emulsion/Solvent Evaporation Method
| Drug |
Dialysis method |
O/W emulsion/solvent evaporation method |
||||
|---|---|---|---|---|---|---|
| PLGA 50:50 (mean ± SEM) % | DL (%) | PLGA 50:50 (mean ± SEM) % | DL (%) | PLGA 65:35 (mean ± SEM) % | DL (%) | |
| DEX | 7.2 ± 3.5 | 0.71 ± 0.11 | 77.3 ± 4.4 | 10.1 ± 1.1 | 76.6 ± 3.1 | 9.9 ± 2.2 |
| HA | 12.1 ± 2.7 | 1.19 ± 0.39 | 91.3 ± 3.5 | 11.2 ± 1.5 | 92.3 ± 2.9 | 12.1 ± 1.4 |
| PA | 14.3 ± 1.3 | 1.40 ± 0.24 | 92.3 ± 5.1 | 10.9 ± 1.2 | 94.3 ± 3.3 | 11.1 ± 0.9 |
Abbreviations: DEX, dexamethasone; DL, drug loading; HA, hydrocortisone acetate; O/W, oil-in-water; PA, prednisolone acetate; PLGA, polylactide-co-glycolide; SEM, standard error of mean.