Table 4. .

Release Rate Constants of Drugs From Nanoparticles Prepared by Dialysis Method, O/W Emulsion/Solvent Evaporation Method, and Formulations

Drug	Dialysis method		O/W emulsion/solvent evaporation method				Formulations (PLGA 65:35 nanoparticles in thermosensitive gels)
	PLGA 50:50		PLGA 50:50		PLGA 65:35
	Q = K t½						Q = K0 t
	K (h−1/2)mean ± SEM	R2	K (h−1/2)mean ± SEM	R2	K (h−1/2)mean ± SEM	R2	K (μg/h)mean ± SEM	R2
DEX	16.0 ± 0.40	0.93	6.73 ± 0.30	0.95	5.11 ± 0.12	0.97	0.24 ± 0.01	0.92
HA	5.40 ± 0.30	0.93	2.24 ± 0.18	0.98	1.31 ± 0.20	0.96	0.21 ± 0.04	0.95
PA	7.10 ± 0.60	0.92	3.40 ± 0.20	0.95	3.16 ± 0.14	0.97	0.23 ± 0.02	0.97

 Abbreviations: DEX, dexamethasone; DL, drug loading; HA, hydrocortisone acetate; O/W, oil-in-water; PA, prednisolone acetate; PLGA, polylactide-co-glycolide; SEM, standard error of mean.