Figure 1.
Partial sequence and domains of wild-type and mutant DYNC1LI1. A, Multiple sequence alignment of cytoplasmic dynein light intermediate chain 1. Asparagine 235 is mutated in the Dync1li1N235Y mouse but is highly conserved throughout the animal kingdom and also in amoebae and fungi. B, Protein domain map of DYNC1LI1, showing the location of the DYNC1LI11N235Y mutation as a red bar. The map was created using the domains identified by Bielli et al. (2001), Hughes et al. (1995), and Tynan et al. (2000).