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. 2011 Apr 6;31(14):5483–5494. doi: 10.1523/JNEUROSCI.5244-10.2011

Figure 2.

Figure 2.

Behavior of Dync1li1N235Y/N235Y mice. A, Dync1li1N235Y/N235 mice displayed significantly lower levels of spontaneous locomotor activity compared with wild-type littermates. B, On the elevated plus maze (EPM), the Dync1li1N235Y/N235Y mice spent significantly less time in the open arms and more time in the closed arms. C, They also made significantly fewer entries to both the open and closed arms. D, On the successive alleys task Dync1li1N235Y/N235Y mice spent less time in the more anxiogenic alleys compared with wild types. E, They also made fewer entries to these alleys (the Dync1li1N235Y/N235Y mice did not make any entries to alleys 3 or 4). F, Footprint analysis using the CatWalk system found that compared with wild types, Dync1li1N235Y/N235Y mice displayed a significantly greater difference between the BOS of their front legs and hind legs due to a relative narrowing of the front BOS and a widening of the hind BOS; a representative sample from one animal is shown. Green, Right front foot; dark green, right hind foot; red, left front foot; dark red, left hind foot. Animals walked from right to left.