Table 1.
Cell profile size distribution in cervical and lumbar DRGs for NFH- and peripherin-positive neurons in wild-type and Dync1li1N235Y/N235Y mice
| Cervical |
Lumbar |
|||
|---|---|---|---|---|
| Wild type (n = 3) | Dync1li1N235Y/N235Y (n = 4) | Wild type (n = 3) | Dync1li1N235Y/N235Y (n = 4) | |
| Total number of NFH-positive profile areas measured | 201 | 286 | 165 | 240 |
| Mean NFH cell profile area | 739 ± 80 (579–833) | 676 ± 37 (568–739) | 773 ± 46 (714–864) | 680 ± 33 (595–734) |
| Total number of peripherin-positive profile areas measured | 338 | 496 | 319 | 430 |
| Mean peripherin cell profile area | 339 ± 32 (279–387) | 307 ± 6 (279–323) | 351 ± 31 (294–299) | 285 ± 18 (245–319) |
For mean ± SEM values, the values in parentheses are ranges.
Neurofilament: There was no significant difference (p > 0.1, Kolmogorov–Smirnov test) in the distribution of the profile areas of cervical NFH-immunoreactive DRG neurons between wild-type mice (719 ± 324 μm2, mean ± SD; ncells = 201, nanimals = 3) and Dync1li1N235Y/N235Y littermates (664 ± 275 μm2, mean ± SD; ncells = 286, nanimals = 4). Data not shown. The distribution of the profile areas of lumbar NFH-immunoreactive DRG neurons is significantly different (p < 0.025, Kolmogorov–Smirnov test) between wild-type mice (765 ± 296 μm2, mean ± SD; ncells = 165, nanimals = 3) and Dync1li1N235Y/N235Y littermates (686 ± 280 μm2, mean ± SD; ncells = 240, nanimals = 4) (Fig. 5B).
Peripherin: The distribution of the profile areas of cervical peripherin-immunoreactive DRG neurons is significantly different (p < 0.025, Kolmogorov–Smirnov test) between wild-type mice (335 ± 152 μm2, mean ± SD; ncells = 338, nanimals = 3) and Dync1li1N235Y/N235Y littermates (307 ± 165 μm2, mean ± SD; ncells = 496, nanimals = 4). Data not shown. The distribution of the profile areas of lumbar peripherin-immunoreactive DRG neurons is significantly different (p < 0.001, Kolmogorov–Smirnov test) between wild-type mice (353 ± 199 μm2, mean ± SD; ncells = 319, nanimals = 3) and Dync1li1N235Y/N235Y littermates (286 ± 151 μm2, mean ± SD; ncells = 430, nanimals = 4) (Fig. 4C).