Figure 3.

Decreased levels of C/EBPα also in brain areas with low Aβ plaque burden from aged tg-ArcSwe mice. Relative abundance and representative western blot of C/EBPα (p30) in forebrain (A) and pathology-spared hindbrain (B) from 15.5-17 month-old tg-ArcSwe mice (tg) and non-transgenic mice (c). The results show a decrease in protein levels in both brain areas indicating that the observed down-regulation does not directly relate to Aβ plaque burden. The data represent mean ± SEM for six transgenic and six control mice. Young transgenic mice did not show significantly altered expression in forebrain (C) or hindbrain (D). The data represent mean ± SEM for three transgenic and five control mice. 40 μg of protein lysate was loaded in each lane and β-actin was used as a loading control. *p < 0.05, significantly different from control. A.U., arbitrary units.