Figure 5.

C/EBPδ levels are decreased with ageing and Aβ plaque formation. Relative abundance (A) and representative western blot (B) of C/EBPδ from forebrain of young and aged tg-ArcSwe mice (tg) and non-transgenic littermates (c). When comparing C/EBPδ levels between young and aged mice, the results indicate an overall C/EBPδ decrease not only in response to Aβ but also to age. The data represent mean ± SEM for five transgenic mice and six control mice. 40 μg of protein lysate was loaded in each lane and β-actin was used as a loading control. ***p < 0.001, significantly different as indicated. A.U., arbitrary units.