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In vitro characterization of in situ formulation
| Formu-ation | pH* | Viscosity* (cps) |
Spreadibility g.cm/s |
Drug Content (%w/w) |
*Muco-adhesive force dynes/cm2 |
Gelling Capacity |
Gel strength g/s |
|---|---|---|---|---|---|---|---|
| F1 | 7.2 | 14000 | 28.5 | 90.4 | 52.5 ± 7.5 | +++ | 6.5 |
* Average of three reading
- No gelation; + Gel after few minutes, dissolved rapidly; ++ Gelation immediately, remains for few hours; +++ Gelation immediately, remains for extended period.
