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Hydrocephalus in Tg737orpk mutants and ciliary defects on the ependymal cells. (A) Very few cilia were present on the ependymal cells lining the ventricles of all the Tg737orpk mutant mice analyzed. (B) In contrast, abundant cilia are present on these cells in the wild-type mice. (C) Hydrocephalus was evident in all mutant mice analyzed. (D) There was no ventricular expansion in any of the wild-type controls.
