TABLE 1.

Characteristics of leukemia specimens examined here^a

Specimen	Subtype	eIF4E result		PRH result		Cyclin D1 result			c-Myc result (Western) (fold increase)	Cytogenetics
		Confocal	Western	Confocal	Western	Western	Northern (nuclear vs cytoplasmic)	Northern total
UPN1	M1	Normal	Normal							NA
UPN2	M1		Normal		Normal	High				46, XX
UPN3	M1	Normal	Normal	Normal	Normal	High	Normal	High		46, XY
UPN4	M1	Normal	Normal	Normal	Normal				Normal	46, XY
UPN5	M1	Normal	Normal	Normal	Normal					46, XX
UPN6	M2 (t8;21)	Normal	Normal	Normal	Normal				Normal	47, XY, +8, t(8;21)
UPN7	M2 (t8;21)		Normal		Normal				Normal	46, XY, t(8;21)
UPN8	M2 (t8;21)	Normal	Normal	Normal	Normal	High	Normal	High		46, XY, t(8;21)
UPN9	M2 (t8;21)		Normal							46, XY, t(8;21)
UPN10	M2	Normal	Normal	Normal	Normal	High		High		NA
UPN11	M2		Normal		Normal				Normal	NA
UPN12	M5	Enlarged	High	Cytoplasmic	Low	High	Cytoplasmic	Normal	High (5)	46, XX
UPN13	M5	Enlarged	High	Cytoplasmic	Low				High (5)	46, XX
UPN14	M4	Enlarged	High	Cytoplasmic	Low	High	Cytoplasmic	Normal	High (5)	47, XY, +9
UPN15	M4	Enlarged	High	Cytoplasmic	Low				High (5)	46, XX
UPN16	M4		High		Low	High				45, XY, −7
UPN17	M4/5		High		Low	High			High (5)	48, XY, +8, +13
UPN18	M5	Enlarged	High	Cytoplasmic	Low	High				45, X, −Y
UPN19	M4/5		High		Low	High				NA
UPN20	M4/5		High		Low	High				NA
UPN21	M5	Enlarged	High	Cytoplasmic	Low					47, XY, der(21),t(17;21)
UPN22	M4	Enlarged	High	Cytoplasmic	Low					46, XX
UPN23	MDS/AML		High		Low	High				NA
UPN24	MDS/AML		High		Low	High				46, XY
UPN25	B-ALL	Normal	Normal	Normal	Normal	High			Normal	NA
UPN26	B-ALL		Normal		Normal				High (2)	46,XX,i(9),der(9)del(9), t(9;9;22), der(22), t(9;22)
UPN27	B-ALL	Normal	Normal	Normal	Normal	High			Normal	Complex
UPN28	B-ALL	Normal	Normal	Normal	Normal					NA
UPN29	B-ALL	“Normal”	High	Disrupted	Normal	High			High (5)	46, XY, t(4;11)
UPN30	B-ALL	Normal	Normal	Normal	Normal				High (2)	46, XY, t(9;22)
UPN31	B-ALL	Normal	Normal	Normal	Normal	High	Normal	High		NA
UPN32	B-ALL		Normal		Normal					NA
UPN33	BC-CML		High		Low				High (5)	BCR/ABL+
UPN34	BC-CML	Enlarged	High	Cytoplasmic	Low	High	Cytoplasmic	Normal		BCR/ABL+
UPN35	BC-CML	Enlarged	High	Cytoplasmic	Low				High (5)	BCR/ABL+
UPN36	BC-CML		High		Low	High				BCR/ABL+
UPN37	BC-CML	Enlarged	High	Cytoplasmic	Low				High (5)	BCR/ABL+
UPN38	BC-CML	Enlarged	High	Cytoplasmic	Low	High				BCR/ABL+
UPN39	BC-CML	Enlarged	High	Cytoplasmic	Low	High			High (5)	BCR/ABL+

^aAbbreviations: UPN, unique patient number; M1 to M5, FAB subtype; MDS/AML, AML arising from myelodysplastic syndrome; B-ALL, B-cell ALL; BC-CML, blast crisis CML; confocal, microscopic image of eIF4E or PRH in nuclear bodies; Western, protein level for the indicated gene product as determined by Western blotting; northern (nuclear vs cytoplasmic), relative nuclear and cytoplasmic distribution of cyclin D1 mRNA; Northern total, relative abundance of total cyclin D1 mRNA; normal, eIF4E bodies were somewhat larger in this, the only t(4;11) specimen examined.