Figure 5.
Inhibition of miR-10b reduces glioma growth in vivo in U87 mouse model. A, Mice with established subcutaneous U87 tumors were injected intratumorally with either inhibitor of miR-10b or corresponding control oligo at days indicated by arrows. Tumor growth was monitored by in vivo Fluc bioluminescence imaging. Each data point represents the mean ±SD. B, Established U87 tumors were injected with either control or miR-10b inhibitor for two days in a row. Two days later, mice were sacrificed and tumors were removed, sectioned, and stained for nuclei using DAPI (blue) and Ki-67 (green).