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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Cancer Res. 2011 Apr 6;71(10):3563–3572. doi: 10.1158/0008-5472.CAN-10-3568

Figure 6.

Figure 6

Analysis of miR-10b function in GBM as suggested by TCGA data. A, Expression of cell cycle genes positively correlates with miR-10b expression in GBM patients. Significantly correlated genes (p<0.0001) were assessed for enrichment level of GO biological processes terms and the enrichment scores are presented in the form of heatmaps, showing the terms in rows. The gradient of red color shows the level of enrichment and black corresponds to no enrichment. Enrichment of all correlated (All), negatively correlated (Negative), and positively correlated (Positive) genes is demonstrated for two miR-10b probes (Probe A and Probe B) used on the TCGA arrays. Correlation for miR-21 and miR-10a is demonstrated for comparison. B, Expression of “positive regulators of cell death” anti-correlates with miR-10b expression in GBM patients. C, Shorten survival of GBM patients is strongly associated with high miR-10 expression. Only three (top 10 miR-10 expressors out of 252 patients, top 63, and top 135) from numerous miR-10-based stratification strategies that exhibit significant association are shown. Log rank test p-values for the difference between two survival curves for the miR-10-high and -low expressor GBM patients are indicated.