. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: J Cell Physiol. 2011 Sep;226(9):2235–2243. doi: 10.1002/jcp.22559

Table 1.

Myocardial function and cardiomyocyte morphology in sedentary (SED) and exercise trained (TR) sham-operated (SHAM) and post-myocardial infarction (MI) rats, including MI rats treated with the angiotensin II type 1 receptor antagonist losartan.

	SHAM		MI		MI Losartan

	SED	TR	SED	TR	SED	TR

LVEDP (mmHg)	3.8±2.4	4.1±2.1	25.7±1.3^a	21.9±1.5^a	18.2±1.2^a ^d	17.7±1.1^a ^d
LVPSP (mmHg)	114.3±5.8	120.0±5.1	100.3±3.1^a	98.3±3.1^a	87.6±4.5^a	88.1±5.2^a
+dP/dt_max (mmHg · ms⁻¹)	8.9±1.1	8.4±1.1	3.4±1.2^a	3.9±1.2^a	4.0±0.9^a	3.7±1.4^a
−dP/dt_max (mmHg · ms⁻¹)	8.8±1.3	8.7±1.1	3.2±1.2^a	3.5±1.1^a	4.3±1.3^a	3.8±1.3^a
Cell Length (μm)	100.9±2.6	110.8±4.2^b	130.1±8.1^a	115.0±4.5^a ^c	117.5±3.2^a ^c	113.2±3.1^a ^c
Cell Width (μm)	22.8±1.3	24.4±0.7^b	30.7±2.6^a	26.7±1.6^a ^c	28.0±1.7^a ^c	26.9±1.9^a ^c
Cell Volume (pL)	17.7±1.3	20.5±0.8^b	30.4±2.9^a	23.4±2.1^a ^c	25.5±1.9^a ^c	23.3±1.8^a ^c

LVEDP: left ventricle end-diastolic pressure, LVPSP: left ventricle peak systolic pressure, (+dP/dt_max: peak rate of left ventricle pressure rise, −dP/dt_max: peak rate of left ventricle pressure fall. Note that SHAM TR rats developed physiologic hypertrophy, and that post-MI rats developed heart failure as defined by LVEDP >15 mmHg; presented with reduced LVPSP and rates of contraction and relaxation of the heart, and developed pathologic hypertrophy, which was reversed by exercise training as well as losartan.

difference from SHAM groups, p<0.01;

difference between SHAM SED and SHAM TR, p<0.01;

difference from MI SED, p<0.01.

difference from MI SED without losartan, p<0.01.

Data are mean±SEM with 8 animals/group.