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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Shock. 2011 Jun;35(6):560–566. doi: 10.1097/SHK.0b013e31820fe5d5

Figure 5. Plasma levels of TNF-α, IL-1β, and IL-10 in after LPS: effect of the peroxynitrite decomposition catalyst FP15.

Figure 5

Endotoxemia was induced in mice with LPS (40 mg/kg i.p.). Plasma levels of selected pro- and anti-inflammatory cytokines were measured at 1.5, 3, 6 and 12 hours. Animals that received LPS showed a marked increase in cytokines levels. FP15 treatment (0.3 mg/kg/h) did not affect circulating levels of TNF-α, IL-1β or IL-10 at any of the time points. Data shown represent mean ± SEM of n=6 animals per group. Whenever error bars are not apparent on the figure, they are contained within the symbols. *P<0.05 indicates a significant increase in cytokine levels when compared with baseline.