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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Clin Cancer Res. 2011 Feb 15;17(10):3478–3489. doi: 10.1158/1078-0432.CCR-10-2372

Figure 3. Tumor cell autophagy in indolent and aggressive melanoma xenografts.

Figure 3

Tumor xenografts were generated in the flanks of nude mice using indolent A375P (n=5) and aggressive C8161 (n=7) melanoma cell lines. (A) Tumor size after 33 days, p=0.001, t-test (B–D)Tumors were processed for EM; (B) Mean number AV/cell; p=0.001, Mann-Whitney test. Representative images of tumor cells from (C) two different A375P tumors and (D) two different C8161 tumors; scale bars: 2μm. (E) Lysates from three separate A375P and C8161 tumors were used for immunoblotting against the autophagy markers LC3, p62 and ATG5, and actin loading control.