Fig. 5.

Differential expression of nuclear receptors in livers of mice bearing extra-hepatic EHS tumor. A. Pie chart showing the expression fold change of all detected nuclear receptors expressed in livers of tumor-bearing mice as compared to control mice. Varying fold changes are denoted as different colored segments with green representing down-regulation and red, up-regulation. B. A tabular listing of altered nuclear receptor expression under the broadly classified physiological/functional subgroups. Five endocrine, 4 adopted orphan and 7 true orphan receptors are seen with altered mRNA expression. Fold changes with p-value ≤ 0.05 were considered significant (n = 5 per group).