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Scheme of MINE and MARs contributing to the maintenance of a structurally and functionally independent c-myc domain. Matrix attachment sites located 80 kb upstream and 50 kb downstream may form a chromosomal loop that permits the association of the c-myc gene with transcriptionally active nuclear territories. The c-myc insulator element, composed of the BE and the CTCF binding element, functions as a boundary that separates active (gray) from inactive (white) chromatin.
