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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Cancer Res. 2011 Apr 5;71(10):3573–3581. doi: 10.1158/0008-5472.CAN-10-4489

Figure 3. Ploidy affects the pattern and growth of tumors that develop in NPcis mice.

Figure 3

A, The frequencies of lymphoma and of brain tumors were not significantly different in trisomic mice compared to euploid. A significantly larger fraction of adrenal tumors (P= 0.0014, Fisher’s exact test) and fewer sarcomas (P= 0.0001, Fisher’s exact test) were observed in trisomic, NP65 mice than in their euploid counterparts. B, Euploid mice without sarcoma (open diamond, n=24) lived longer than mice with sarcoma (filled diamond, n=78, *P = 0.026 by Log-rank test). C, Trisomic mice without sarcoma (n=16) lived longer than those with sarcoma (n=10, *P = 0.042 by Kruskal-Wallis test). D, Median survival times were the same in trisomic and euploid mice with sarcoma (P=0.168). E) Trisomic mice with non-sarcoma tumors lived longer than euploid mice with non-sarcoma tumors (*P=0.0017).

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