Table 4.
Sex-specific parameter estimates of natural log-transformed UACR modeled as a function of adiposity measuresa
Minimal model | Multivariable model | |||
---|---|---|---|---|
Parameter estimate | p-value | Parameter estimate | p-value | |
Women | ||||
Visceral adipose tissue | 0.03 | 0.2 | −0.04 | 0.1 |
Subcutaneous adipose tissue | −0.04 | 0.08 | −0.08 | 0.0005 |
Body mass index | −0.02 | 0.3 | −0.08 | 0.002 |
Waist circumference | −0.02 | 0.4 | −0.08 | 0.001 |
Men | ||||
Visceral adipose tissue | 0.13 | <0.0001 | 0.07 | 0.003 |
Subcutaneous adipose tissue | 0.07 | 0.0002 | 0.04 | 0.09 |
Body mass index | 0.12 | <0.0001 | 0.07 | 0.002 |
Waist circumference | 0.09 | <0.0001 | 0.05 | 0.03 |
Abbreviation: UACR=urinary albumin-to-creatinine ratio
Note: Adipose measures standardized to a mean of 0 and standard deviation of 1. Parameter estimates are expressed per standard deviation increase in each fat measure.
P-values for sex-interactions in minimal model: visceral adipose tissue, p=0.0008; subcutaneous adipose tissue, p=0.0002, body mass index, p<0.0001; waist circumference, p<0.0001.
Adjusted for age, current smoking status, alcohol use, menopausal status (women only) and hormone replacement therapy use (women only).
Adjusted for minimal model covariates + current hypertension medication use, systolic blood pressure, and diabetes status.