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. Author manuscript; available in PMC: 2012 May 15.

Published in final edited form as: Clin Cancer Res. 2011 Mar 29;17(10):3388–3397. doi: 10.1158/1078-0432.CCR-10-2876

Table 5.

Two-compartmental pharmacokinetic parameters by dose level

Parameter	Dose Level
Parameter	1 (n=8)^*	2 (n=6)	3 (n=3)
AUC (h^* ng/ml)	1,561 ± 311^†	2,500 ± 813	1,865 ± 723
K10 (1/h)	0.803 ± 0.237	1.04 ± 0.438	0.569 ± 0.169
V1 (ml/m²)	18,512 ± 8,687	14,888 ± 7,685	31,380 ± 7,368
V2 (ml/m²)	66,367 ± 69,511	111,642 ± 130,871	48,448 ± 23,397
CL (ml/h/m²)	13,243 ± 2,540	12,825 ± 3,267	18,137 ± 8,097

^*

“n” represents the number of doses per dose level.

^†

Data are presented as the mean ± standard deviation.