FIG. 3.

α4 integrin-null progenitor numbers in the PB, BM, and spleen over time. (A) PB progenitor levels in Mx.cre⁺α4^+/+ and Mx.cre⁺α4^Δ/Δ mice (n = 4 per genotype) were monitored over time. The animals were euthanized 28 weeks after induced deletion, and the progenitor contents of the BM and spleen were assessed in CFU-C assays. White bars, Mx.cre⁺α4^+/+ mice; black bars, Mx.cre⁺α4^Δ/Δ mice. (B) PB progenitor levels of nonsplenectomized and splenectomized Mx.cre⁺α4^Δ/Δ mice (n = 4 per group) were monitored over time. Black bars, nonsplenectomized Mx.cre⁺α4^Δ/Δ mice; striped bars, splenectomized Mx.cre⁺α4^Δ/Δ mice. (C) The BM progenitor content of splenectomized Mx.cre⁺α4^+/+ and Mx.cre⁺α4^Δ/Δ mice (n = 4 per genotype) was assessed 50 weeks after induced deletion. White bar, splenectomized Mx.cre⁺α4^+/+ mice; striped bar, splenectomized Mx.cre⁺α4^Δ/Δ mice.