FIG. 6.

α4 integrin-deficient progenitors have reduced BM homing. BM cells from Mx.cre⁺α4^+/+ or Mx.cre⁺α4^Δ/Δ mice were injected without prior treatment (A) or after incubation with an anti-LFA-1 antibody (B) into irradiated recipient mice (n = 5 recipients per donor genotype). These animals were euthanized 24 h later, and the progenitor content of the BM, PB, and spleen was assessed by CFU-C assays.