Table 4.
Distribution of Biomarker Values and Percent Differences (Unadjusted and Adjusted) Between Case Patients With Immune Reconstitution Inflammatory Syndrome (IRIS) Events and Non-IRIS Events
| Biomarker | IRIS case patients (N = 28) | Non-IRIS case patients (N = 35) | Unadjusted difference, % | Adjusted difference, a % (95% CI) | P |
| Baseline (pre-ART) | |||||
| D-dimer, mg/L | 1.4 (0.6–2.1) | 1.2 (0.6–2.6) | 7.8 | –9.1 (–45.6 to 51.9) | .72 |
| CRP, mg/L | 4.4 (1.8–11.7) | 5.4 (1.1–17.6) | 8.2 | 26.2 (–53.3 to 241.0) | .65 |
| IL-6, pg/mL | 4.3 (2.9–7.5) | 3.5 (2.0–5.8) | 24.6 | 25.6 (–20.5 to 98.3) | .33 |
| IL-8, pg/mL | 10.5 (5.2–15.3) | 6.4 (4.2–12.1) | 37.1 | 35.8 (–13.7 to 113.6) | .19 |
| IL-10, pg/mL | 8.9 (5.7–16.2) | 8.3 (4.9–13.4) | 27.9 | 19.4 (–36.2 to 123.7) | .58 |
| IFN-γ, pg/mL | 5.0 (2.0–8.7) | 2.3 (1.3–5.1) | 49.1 | –2.4 (–45.6 to 75.1) | .94 |
| TNF-α, pg/mL | 21.9 (16.3–27.9) | 14.8 (11.1–21.5) | 32.7 | 41.6 (6.7–88.0) | .02 |
| HA, ng/mL | 79.2 (52.1–158) | 49.9 (49.9–125) | 12.9 | 11.6 (–23.3 to 62.3) | .57 |
| CXCL10, mg/L | 0.6 (0.4–1.0) | 0.6 (0.3–1.5) | 4.6 | –13.7 (–45.6 to 36.9) | .53 |
| sCD14, x106 pg/mL | 2.9 (2.5–3.2) | 2.4 (1.9–3.0) | 36.6 | 31.7 (0.6–72.5) | .05 |
| Month 1 | |||||
| D-dimer, mg/L | 1.4 (1.0–2.3) | 0.9 (0.5–1.6) | 116.0 | 122.1 (38.4–256.7) | .002 |
| CRP, mg/L | 39.6 (9.1–109) | 6.3 (1.9–17.5) | 364.3 | 280.0 (70.4–747.7) | .002 |
| IL-6, pg/mL | 7.8 (3.1–16.5) | 3.4 (2.2–5.7) | 136.5 | 175.7 (49.6–408.3) | .002 |
| IL-8, pg/mL | 10.4 (5.2–21.9) | 7.2 (3.7–11.5) | 74.3 | 59.0 (–3.5 to 161.9) | .07 |
| IL-10, pg/mL | 7.9 (6.1–20.5) | 6.2 (4.6–9.6) | 23.4 | 15.7 (–28.7 to 87.5) | .56 |
| IFN-γ, pg/mL | 4.5 (2.5–19.6) | 1.7 (1.3–3.4) | 174.2 | 145.4 (22.2–392.9) | .01 |
| TNF-α, pg/mL | 22.7 (16.9–37.9) | 13.1 (9.5–21.9) | 77.2 | 29.3 (–8.6 to 83.1) | .15 |
| HA, ng/mL | 49.9 (49.9–79.5) | 49.9 (49.9–61.8) | –4.7 | –4.8 (–26.5 to 23.3) | .71 |
| CXCL10, mg/L | 0.5 (0.3–1.6) | 0.2 (0.2–0.6) | 90.6 | 133.8 (33.1–310.4) | .005 |
| sCD14, x106 pg/mL | 2.9 (2.4–3.2) | 2.6 (2.0–2.9) | 22.8 | 27.0 (–63 to 72.0) | .13 |
NOTE. Data are median (IQR) unless otherwise specified. CI, confidence interval; CRP, C-reactive protein; HA, hyaluronic acid; IFN-γ, interferon-γ; IL-6, interleukin 6; IL-8, interleukin 8; IL-10, interleukin 10; IQR, interquartile range; OR, odds ratio; TNF-α, tumor necrosis factor α.
a
Adjusted for baseline CD4 T-cell count, human immunodeficiency virus RNA level, triglyceride levels, and prior AIDS events. The models for month 1 are also adjusted for the baseline biomarker level.