Table 3.
Sensitivity, specificity, PPV, and NPV of lung, colorectal, breast, and prostate cancer reports*
| Categories of relatives (total N, No. of positive reports, No. of true-positive reports)† | % (95% CI) |
|||
| Sensitivity | Specificity | PPV | NPV | |
| Lung cancer | ||||
| All eligible relatives (2605, 105, 55) | 60.2 (46.5 to 72.4) | 98.3 (97.3 to 98.9) | 40.0 (26.4 to 55.4) | 99.2 (98.8 to 99.5) |
| First-degree relatives (1361, 47, 36) | 71.3 (52.8 to 84.7) | 99.7 (99.3 to 99.9) | 78.1 (59.3 to 89.7) | 99.6 (99.1 to 99.8) |
| Second-degree relatives (1244, 58, 19) | 55.5 (37.3 to 72.3) | 97.5 (96.1 to 98.5) | 31.7 (18.0 to 49.6) | 99.1 (98.5 to 99.4) |
| P < .001‡ | P < .001‡ | |||
| Completed living relative/proxy interview (1118, 38, 31) | 55.7 (38.3 to 71.9) | 99.0 (96.3 to 99.7) | 63.2 (24.0 to 90.4) | 98.6 (97.6 to 99.2) |
| Not completed living relative/proxy interview (1487, 67, 24) | 68.5 (41.6 to 86.9) | 97.9 (96.6 to 98.7) | 25.7 (13.1 to 44.2) | 99.7 (99.3 to 99.8) |
| P = .02§ | ||||
| Relatives of male respondents (1004, 44, 20) | 55.0 (31.2 to 76.7) | 97.6 (95.3 to 98.8) | 29.2 (13.6 to 52.0) | 99.2 (98.4 to 99.6) |
| Relatives of female respondents (1601, 61, 35) | 64.4 (45.3 to |79.8) | 98.9 (98.1 to 99.4) | 54.0 (35.3 to 71.6) | 99.3 (98.8 to 99.6) |
| Relatives of respondents aged 25–44 y (1017, 53, 30) | 73.2 (56.3 to 85.3) | 97.9 (96.0 to 98.9) | 48.3 (27.8 to 69.3) | 99.3 (98.5 to 99.6) |
| Relatives of respondents aged 45–64 y (1588, 52, 25) | 34.9 (20.9 to 52.3) | 98.7 (97.4 to 99.3) | 23.7 (12.0 to 41.5) | 99.2 (98.6 to 99.6) |
| P < .001|| | ||||
| Relatives of respondents with high school/vocational/technical school degree or less (799, 37, 19) | 64.2 (38.2 to 83.8) | 97.9 (95.0 to 99.1) | 39.3 (15.2 to 69.9) | 99.2 (98.5 to 99.6) |
| Relatives of respondents with some college education or more (1804, 68, 36) | 58.1 (40.7 to 73.7) | 98.5 (97.4 to 99.1) | 40.5 (24.2 to 59.2) | 99.3 (98.7 to 99.6) |
| Colorectal cancer | ||||
| All eligible relatives (2605, 58, 40) | 27.3 (16.7 to 41.3) | 99.4 (98.8 to 99.7) | 53.5 (33.0 to 72.8) | 98.1 (96.6 to 98.9) |
| First-degree relatives (1361, 34, 29) | 26.8 (6.2 to 66.9) | 99.9 (99.6 to 100.0) | 85.8 (63.9 to 95.3) | 97.9 (93.8 to 99.3) |
| Second-degree relatives (1244, 24, 11) | 27.6 (15.1 to 45.1) | 99.1 (98.1 to 99.5) | 43.5 (21.6 to 68.3) | 98.2 (97.1 to 98.8) |
| P = .02‡ | P = .004‡ | |||
| Completed living relative/proxy interview (1118, 26, 25) | 34.9 (14.6 to 62.8) | 99.8 (98.8 to 100.0) | 90.4 (49.3 to 98.9) | 97.3 (93.1 to 98.9) |
| Not completed living relative/proxy interview (1487, 32, 15) | 14.4 (7.3 to 26.3) | 99.0 (98.1 to 99.5) | 20.0 (8.1 to 41.4) | 98.6 (97.6 to 99.2) |
| P = .04§ | P < .001§ | |||
| Relatives of male respondents (1004, 26, 19) | 27.5 (11.5 to 52.4) | 99.4 (98.4 to 99.8) | 60.1 (30.4 to 83.8) | 97.6 (94.1 to 99.0) |
| Relatives of female respondents (1601, 32, 21) | 27.1 (13.9 to 46.0) | 99.3 (98.3 to 99.7) | 46.0 (17.7 to 77.2) | 98.5 (97.6 to 99.0) |
| Relatives of respondents aged 25–44 y (1017, 22, 15) | 29.0 (13.6 to 51.4) | 99.4 (98.5 to 99.8) | 63.1 (33.2 to 85.5) | 97.5 (94.7 to 98.8) |
| Relatives of respondents aged 45–64 y (1588, 36, 25) | 24.7 (14.6 to 38.8) | 99.3 (98.4 to 99.7) | 42.0 (16.7 to 72.4) | 98.5 (97.5 to 99.1) |
| Relatives of respondents with high school/vocational/technical school degree or less (799, 14, 9) | 30.3 (12.5 to 57.1) | 99.4 (97.2 to 99.9) | 52.8 (9.1 to 92.6) | 98.4 (96.9 to 99.1) |
| Relatives of respondents with some college education or more (1804, 44, 31) | 26.2 (13.6 to 44.3) | 99.4 (98.7 to 99.7) | 53.7 (30.8 to 75.1) | 97.9 (95.8 to 99.0) |
| Breast cancer | ||||
| All eligible relatives (1433, 119, 77) | 61.1 (48.3 to 72.5) | 98.1 (97.0 to 98.8) | 61.3 (47.1 to 73.8) | 98.1 (97.1 to 98.7) |
| First-degree relatives (750, 60, 45) | 64.9 (49.6 to 77.6) | 99.0 (98.2 to 99.5) | 79.9 (66.1 to 89.0) | 97.9 (96.4 to 98.7) |
| Second-degree relatives (683, 59, 32) | 59.0 (39.9 to 75.7) | 97.7 (96.1 to 98.7) | 53.6 (35.0 to 71.3) | 98.1 (96.7 to 98.9) |
| P = .02‡ | P = .02‡ | |||
| Completed living relative/proxy interview (640, 66, 59) | 66.4 (51.6 to 78.6) | 99.1 (97.9 to 99.7) | 88.8 (75.2 to 95.4) | 96.6 (94.5 to 98.0) |
| Not completed living relative/proxy interview (793, 53, 18) | 49.3 (26.7 to 72.2) | 97.5 (95.7 to 98.6) | 31.9 (16.8 to 52.0) | 98.8 (97.7 to 99.4) |
| P = .02§ | P < .001§ | P = .05§ | ||
| Relatives of male respondents (538, 44, 28) | 56.6 (35.5 to 75.5) | 98.0 (95.6 to 99.1) | 57.6 (32.8 to 79.0) | 97.9 (95.9 to 98.9) |
| Relatives of female respondents (895, 75, 49) | 64.5 (48.6 to 77.8) | 98.1 (96.7 to 99.0) | 64.1 (46.5 to 78.5) | 98.2 (97.0 to 98.9) |
| Relatives of respondents aged 25–44 y (546, 45, 31) | 68.9 (51.8 to 82.0) | 98.2 (96.1 to 99.2) | 67.8 (43.4 to 85.3) | 98.3 (96.9 to 99.1) |
| Relatives of respondents aged 45–64 y (887, 74, 46) | 52.6 (35.2 to 69.4) | 97.9 (96.4 to 98.8) | 53.9 (36.6 to 70.4) | 97.8 (96.4 to 98.7) |
| Relatives of respondents with high school/vocational/technical school degree or less (435, 36, 21) | 71.8 (41.9 to 90.9) | 97.7 (95.1 to 99.0) | 56.4 (32.4 to 77.8) | 98.8 (97.1 to 99.5) |
| Relatives of respondents with some college education or more (997, 83, 56) | 57.7 (42.4 to 71.6) | 98.2 (96.8 to 99.0) | 63.5 (44.2 to 79.2) | 97.7 (96.4 to 98.6) |
| Prostate cancer | ||||
| All eligible relatives (1172, 57, 42) | 32.0 (21.4 to 45.0) | 98.6 (97.2 to 99.3) | 53.4 (35.7 to 70.3) | 96.9 (94.8 to 97.8) |
| First-degree relatives (611, 44, 36) | 58.9 (43.1 to 73.1) | 98.9 (96.2 to 99.7) | 64.7 (30.7 to 88.4) | 98.6 (96.9 to 99.4) |
| Second-degree relatives (561, 13, 6) | 21.5 (9.5 to 41.7) | 98.3 (96.3 to 99.3) | 45.0 (18.1 to 75.2) | 95.1 (92.6 to 96.8) |
| P = .002‡ | P = .01‡ | |||
| Completed living relative/proxy interview (478, 31, 29) | 41.1 (25.7 to 58.5) | 99.2 (96.5 to 99.8) | 80.0 (44.3 to 95.3 | 95.7 (91.1 to 98.0) |
| Not completed living relative/proxy interview (694, 26, 13) | 14.5 (7.2 to 26.9) | 98.1 (96.0 to 99.1) | 19.0 (8.5 to 37.1) | 97.4 (95.4 to 98.5) |
| P = .01§ | P < .001§ | |||
| Relatives of male respondents (466, 26, 19) | 28.6 (14.2 to 49.3) | 98.5 (95.7 to 99.5) | 54.4 (25.3 to 80.8) | 95.7 (91.8 to 97.8) |
| Relatives of female respondents (706, 31, 23) | 37.1 (23.1 to 53.7) | 98.7 (96.5 to 99.5) | 52.3 (24.9 to 78.4) | 97.5 (95.9 to 98.5) |
| Relatives of respondents aged 25–44 y (471, 22, 13) | 31.2 (16.0 to 51.9) | 98.4 (96.0 to 99.4) | 56.4 (28.1 to 81.1) | 95.7 (93.1 to 97.4) |
| Relatives of respondents aged 45–64 y (701, 35, 29) | 33.0 (18.1 to 52.4) | 98.7 (96.3 to 99.5) | 50.4 (26.5 to 74.2) | 97.3 (94.6 to 98.7) |
| Relatives of respondents with high school/vocational/technical school degree or less (364, 13, 9) | 33.0 (9.8 to 69.2) | 98.8 (95.4 to 99.7) | 46.7 (10.1 to 87.3) | 97.8 (94.6 to 99.1) |
| Relatives of respondents with some college education or more (807, 44, 33) | 31.7 (20.5 to 45.6) | 98.5 (96.6 to 99.4) | 55.6 (34.6 to 74.9) | 96.1 (93.5 to 97.6) |
*
Weighted for the population of the state of Connecticut. CI = confidence interval; NPV = negative predictive value; PPV = positive predictive value.
†
Unweighted numbers.
‡
Two-sided pairwise t tests between reports on first-degree relatives vs second-degree relatives.
§
Two-sided pairwise t tests between completed living relative/proxy interviews vs not completed living relative/proxy interviews.
||
Two-sided pairwise t tests of reports by respondents aged 25–44 years vs respondents aged 45–64 years.