Figure 3.

Nicotine self-administration in WT and α4-S248F mice at 0.03 mg/kg/infusion (n=7 WT, 10 α4-S248F), 0.05 mg/kg/infusion (n=13 WT, 9 α4-S248F), and 0.07 mg/kg/infusion (n=14 WT, 6 α4-S248F). (a) Average number of nicotine infusions administered in a 2 h session. (b) Average number of active lever presses. (c) Average percentage of lever presses on the active, drug-paired lever. For (a, b, c) average response was taken as the mean response of each mouse over five stable daily self-administration sessions, and these expressed as mean (±SEM) for each genotype and dose. (d) Percentage of mice achieving self-administration criteria of at least 10 active lever presses, with at least 70% lever discrimination over 3 days for each genotype and dose. ^*p<0.05, 0.03 vs 0.07, within genotype, ^p<0.05, WT vs α4-S248F within dose (post-hoc Tukey's test following two-way ANOVA).