Figure 7.

Effect of mecamylamine pretreatment on nicotine (0.07 mg/kg/infusion) self-administration in C57Bl6 mice (n=11). (a) Number of nicotine infusions administered by mice treated with either vehicle (saline) or mecamylamine. (b) Percentage of discrimination between the active, reward-paired lever, and inactive lever of mice treated with either vehicle or mecamylamine. Vehicle data are the average of three separate vehicle treatment sessions, preceding each mecamylamine treatment session. ^*p<0.05, post-hoc Holm–Sidak test following one-way repeated measures ANOVA.