Figure 5.

Toluene-induced inhibition of AMPA EPSCs is blocked by either the ryanodine receptor dantrolene or sarco/endoplasmic reticulum Ca²⁺/ATPase inhibitor thapsigargin. (a) Time-course of AMPA-mediated EPSCs before, during, and after 3 mM toluene exposure. Data are expressed as a percent of averaged baseline response. (b) Summary of effects of toluene on AMPA-mediated currents under control conditions or in the presence of either dantrolene or thapsigargin. ^**Values significantly different from baseline amplitudes. (p<0.01, repeated measures ANOVA, post hoc Dunnett's multiple comparison test). Data are mean±SEM. The color reproduction of this figure available on the HTML full text version of the paper.