Figure 9.

Effects of the CB1 receptor antagonist AM-281 on toluene-induced inhibition of NMDA-mediated EPSCs. (a) Traces show representative examples of stimulus evoked NMDA EPSCs currents before, during, and after washout of a 3 mM toluene solution. All recordings were carried out in the presence of the CB1 antagonist AM-281 (0.75 μM). (b) Time-course of 3 mM toluene's inhibition of NMDA-mediated currents recorded with normal or AM-281 containing aCSF. Data are expressed as a percent of the averaged baseline response (c) Summary of effects of toluene on NMDA-mediated currents in the presence or absence of 0.75 μM AM-281. Data are expressed as a percent of the averaged baseline response. Asterisks are the values that are significantly different from baseline amplitude (^*p<0.05, ^**p<0.01; repeated measures ANOVA, Dunnett's multiple comparison test). Data are mean±SEM. The color reproduction of this figure available on the HTML full text version of the paper.