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. 2011 Mar 16;36(7):1319–1331. doi: 10.1038/npp.2011.8

Figure 4.

Figure 4

Effect of nicotine pretreatment on quinpirole-induced locomotion is specific to early adolescence and persists 10 days. Adolescent postnatal day ((P)32) and adult (P90) animals were given intravenously nicotine or saline daily for 4 days before drug injection. Time course of ambulatory counts during 30 min after drug injection. Nicotine-treated P32 rats showed a significant enhancement of locomotor activity after quinpirole administration compared with saline-treated controls (P28–P31 Test: P32, a). Nicotine enhancement of quinpirole-induced locomotion was not seen when animals were pretreated during adulthood (P86–89 Test: P90, b) or late adolescence (P37–40 Test: P41, c). However, if pretreated in early adolescence, the enhanced quinpirole-induced locomotion was still evident when tested 10 days later (P28–31 Test: P41, d). +++p<0.0001, ++p<0.002, +p=0.01 vs Sal/Quin (0.4). n=6–14 per P32 and 90 groups. n=7–8 per P41 groups.